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López Rodríguez, Ana Belén ; Mela Rivas, Virginia ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel ; Viveros, María Paz | Elsevier | 2016-05Background and purpose The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16 kDa peptidic hormone is mainly kn[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Viveros, María Paz ; García Segura, Luis Miguel | Public Library of Sciences (PLOS) | 2015-06-03Traumatic brain injury (TBI) incidence rises during adolescence because during this critical neurodevelopmental period some risky behaviors increase. The purpose of this study was to assess the contribution of cannabinoid receptors (CB1 and CB2)[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Elsevier | 2015-06Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective str[...]texto impreso
Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
Acaz Fonseca, Estefanía ; Ortiz Rodriguez, Ana ; López Rodríguez, Ana Belén ; García Segura, Luis Miguel ; Astiz, Mariana | Springer Nature | 2017-03-06Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC[...]texto impreso
Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; Santos Galindo, María ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel | Academic Press Inc Elsevier Science | 2013-02Astrocytes and microglia respond to central nervous system (CNS) injury with changes in morphology, proliferation, migration and expression of inflammatory regulators. This phenomenon is known as reactive gliosis. Activation of astrocytes and mi[...]texto impreso
Acaz Fonseca, Estefanía ; Ortiz Rodriguez, Ana ; Azcoitia Elías, Iñigo ; García-Segura, Luis Miguel ; Arévalo, María Ángeles | Springer | 2019-04-03In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored t[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Spezzano, Roberto ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Endocrine Society | 2016The incidence of traumatic brain injuries (TBIs) in humans has rapidly increased in the last ten years. The most common causes are falls and car accidents. Approximately 80 000-90 000 persons per year will suffer some permanent disability as a r[...]
