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Background and rationale Polydrug use is a widespread phenomenon, especially among adolescents and young adults. Synthetic cathinones are frequently consumed in combination with other drugs of abuse. However, there is very little information reg[...]texto impreso
Mela Rivas, Virginia ; Jiménez, Sara ; Freire Regatillo, Alejandra ; Barrios, Vicente ; Marco López, Eva ; López Rodríguez, Ana Belén ; Argente, Jesús ; Viveros, María Paz ; Chowen, Julie A. | Elsevier | 2016-12The neonatal leptin surge, occurring from postnatal day (PND) 5 to 13 and peaking at PND9 in rodents, is important for the development of neuroendocrine circuits involved in metabolic control and reproductive function. We previously demonstrated[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; López Rodríguez, Ana Belén ; Vázquez, María Jesús ; Gertler, Arieh ; Argente, Jesús ; Tena-Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Oxford University Press | 2015-07Leptin is important in the development of neuroendocrine circuits involved in metabolic control. As both leptin and metabolism influence pubertal development, we hypothesized that early changes in leptin signaling could also modulate hypothalami[...]texto impreso
López Rodríguez, Ana Belén ; Siopi, Eleni ; Finn, David P. ; Marchand-Leroux, Catherine ; García Segura, Luis Miguel ; Jafarian-Tehrani, Mehrnaz ; Viveros, María Paz | Oxford Open | 2015-01Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impa[...]texto impreso
López Rodríguez, Ana Belén ; Mela Rivas, Virginia ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel ; Viveros, María Paz | Elsevier | 2016-05Background and purpose The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16 kDa peptidic hormone is mainly kn[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Viveros, María Paz ; García Segura, Luis Miguel | Public Library of Sciences (PLOS) | 2015-06-03Traumatic brain injury (TBI) incidence rises during adolescence because during this critical neurodevelopmental period some risky behaviors increase. The purpose of this study was to assess the contribution of cannabinoid receptors (CB1 and CB2)[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Elsevier | 2015-06Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective str[...]texto impreso
Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
Acaz Fonseca, Estefanía ; Ortiz Rodriguez, Ana ; López Rodríguez, Ana Belén ; García Segura, Luis Miguel ; Astiz, Mariana | Springer Nature | 2017-03-06Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC[...]texto impreso
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López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Spezzano, Roberto ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Endocrine Society | 2016The incidence of traumatic brain injuries (TBIs) in humans has rapidly increased in the last ten years. The most common causes are falls and car accidents. Approximately 80 000-90 000 persons per year will suffer some permanent disability as a r[...]texto impreso
Hennessy, Edel ; Gormley, Shane ; López Rodríguez, Ana Belén ; Murray, Caoimhe ; Murray, Carol ; Cunningham, Colm | Elsevier | 2017Inflammation influences chronic neurodegeneration but its precise roles are not yet clear. Systemic inflammation caused by infection, trauma or co-morbidity can alter the brain’s inflammatory status, produce acute cognitive impairments, such as [...]texto impreso
Viveros, María Paz ; Bermúdez-Silva, Francisco-Javier ; López Rodríguez, Ana Belén ; Wagner, Edward J. | MDPI | 2011-07-28The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostas[...]
