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Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
Baeza, Alejandro ; Guisasola, Eduardo ; Torres Pardo, Almudena ; González Calbet, José M. ; Melen, Gustavo J. ; Ramírez, Manuel ; Vallet Regí, María | Wiley | 2014-08-06A novel nanocarrier based on functionalized mesoporous silica nanoparticles able to transport a non-toxic pro-drug and the enzyme responsible for its activation is presented. This nanodevice is able to generate in situ cytotoxic species once acc[...]texto impreso
Entrena Martínez, Ana ; Varas, Alberto ; Vázquez, Miriam ; Melen, Gustavo J. ; Fernández Sevilla, Lidia M. ; García Castro, Javier ; Ramírez, Manuel ; Zapata González, Agustín Gregorio ; Vicente, Ángeles | Elsevier | 2015-07-28Mesenchymal stem cells (MSCs) are key components of the bone marrow microenvironment which contribute to the maintenance of the hematopoietic stem cell niche and exert immunoregulatory functions in innate and adaptive immunity. We analyze the im[...]texto impreso
Villaverde, Gonzalo ; Alfranca, Arantzazú ; González-Murillo, África ; Melen, Gustavo J. ; Castillo, Rafael R. ; Ramírez, Manuel ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH | 2018-12-10The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoratio[...]texto impreso
Villaverde, Gonzalo ; Baeza, Alejandro ; Melen, Gustavo J. ; Alfranca, Arantzazú ; Ramírez, Manuel ; Vallet Regí, María | Royal Society of Chemistry | 2015-04-14Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporo[...]texto impreso
Robson, Neil C. ; Hidalgo, Laura ; McAlpine, Tristan ; Wei, Heng ; Martínez, Víctor G. ; Entrena Martínez, Ana ; Melen, Gustavo J. ; MacDonald, Andrew S. ; Phythian-Adams, Alexander ; Sacedón, Rosa ; Maraskovsky, Eugene ; Cebon, Jonathan ; Ramírez, Manuel ; Vicente, Ángeles ; Varas, Alberto | American Association for Cancer Research | 2018-09Natural killer (NK) cells are critical for innate tumor immunity due to their specialized ability to recognize and kill neoplastically transformed cells. However, NK cells require a specific set of cytokine-mediated signals to achieve optimal ef[...]
