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Alkozi, Hanan Awad ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Carracedo Rodríguez, Juan Gonzalo ; Fonseca, Begoña ; Martínez Águila, Alejandro ; Pintor, Jesús | John Wiley & Sons Ltd. | 2016-09-06Purpose: To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods : A total of 37 eyes of 37 patients who underwent ca[...]texto impreso
Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year [...]texto impreso
Reyes Resina, Irene ; Alkozi, Hanan Awad ; Ser-Badia, Anna, del ; Sánchez Naves, Juan ; Lillo, Jaume ; Jiménez Cano, Jasmina ; Pintor, Jesús ; Navarro Brugal, Gemma ; Franco Fernández, Rafael | MDPI | 2020-01-08Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. The underlying mechanisms are not [...]texto impreso
Melatonin is a neurohormone synthesized in the pineal gland as well as in other organs and it plays an important role in many ocular functions, as it is synthesized in numerous eye structures. Melatonin can reduce the intraocular pressure and to[...]texto impreso
Melatonin is not only synthesized by the pineal gland but by several ocular structures. This natural indoleamine is of great importance for regulating several eye processes, among which pressure homeostasis is included. Glaucoma, the most preval[...]texto impreso
Melatonin is a substance synthesized in the pineal gland as well as in other organs. This substance is involved in many ocular functions, giving its synthesis in numerous eye structures. Melatonin is synthesized from serotonin through two enzyme[...]texto impreso
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in hum[...]texto impreso
Dry eye syndrome is a common tears and ocular surface multifactorial disease, described by changes in the ocular surface epithelia related to reduced tears quantity and ocular surface sensitivity, leading to inflammatory reaction. Managing the e[...]texto impreso
Rivas Santisteban, Rafael ; Reyes Resina, Irene ; Raich, Iu ; Pintor, Jesús ; Alkozi, Hanan Awad ; Navarro Brugal, Gemma ; Franco Fernández, Rafael | San Antonio TX | 2019-12-15This is a pre-registered study, i.e. a study whose hypotheses and experiments designed to address these hypotheses have been deposited in a database before starting the experiments. The study aims at assessing the Gs versus Gi coupling and the p[...]texto impreso
TRPV4 activation triggers the release of melatonin from human non-pigmented ciliary epithelial cells
Melatonin is a neurohormone mainly produced in the pineal gland; nevertheless, various ocular structures such as the ciliary body, lens and the retina produce it. One of the roles of melatonin in the eye is the modulation of intraocular pressure[...]texto impreso
Alkozi, Hanan Awad ; Pérez de Lara, María Jesús ; Sánchez Naves, Juan ; Pintor, Jesús | MDPI | 2017-04Melatonin is a molecule which has gained a great deal of interest in many areas of science; its synthesis was classically known to be in the pineal gland. However, many organs synthesize melatonin, such as several ocular structures. Melatonin is[...]texto impreso
LLedó Mayans, Victoria Eugenia ; Alkozi, Hanan Awad ; Pintor Just, Jesús | Taylor & Francis | 2019-01-24Purpose: Melatonin is a neurohormone mainly synthesized in the pineal gland; however, it is also present in the aqueous humor. One of melatonins’ functions in the eye is the regulation of intraocular pressure (IOP). Melatonin is known to be sens[...]
