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Francisco Martínez, Patricia de ; Amaro Torres, Francisco ; Martín González, Ana María ; Gutiérrez Fernández, Juan Carlos | University of Geneva | 2018-10-23Metallothioneins (MT) are multi-stress proteins mainly involved in metal detoxification. MT gene expression is normally induced by a broad variety of stimulus and its gene expression regulation mainly occurs at a transcriptional level. Conserved[...]texto impreso
Gutiérrez Fernández, Juan Carlos ; Amaro Torres, Francisco ; Díaz del Toro, Silvia ; Martín González, Ana María | Springer | 2020-01In this mini-review, the potential of using microorganisms to design biosensors for detecting environmental pollutants is analyzed and discussed. A distinction is made between a classical biosensor (CB) and a whole-cell biosensor (WCB), emphasiz[...]texto impreso
Francisco Martínez, Patricia de ; Martín González, Ana María ; Turkewitz, Aaron P. ; Gutiérrez Fernández, Juan Carlos | PLOS | 2017Metallothioneins (MT) constitute a superfamily of small cytosolic proteins that are able to bind metal cations through numerous cysteine (Cys) residues. Like other organisms the ciliate Tetrahymena thermophila presents several MT isoforms, which[...]texto impreso
Gutiérrez Fernández, Juan Carlos ; Amaro Torres, Francisco ; Martín González, Ana María | Frontiers Media | 2015-02-20This review analyzes the advantages and disadvantages of using eukaryotic microorganisms to design whole-cell biosensors (WCBs) for monitoring environmental heavy metal pollution in soil or aquatic habitats. Basic considerations for designing a [...]texto impreso
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Espart, Anna ; Marín, Maribel ; Gil Moreno, Selene ; Palacios, Óscar ; Amaro Torres, Francisco ; Martín González, Ana María ; Gutiérrez Fernández, Juan Carlos ; Capdevilla, Mercé ; Atrian, Sílvia | Ivyspring International Publisher | 2015The metal binding preference of metallothioneins (MTs) groups them in two extreme subsets, the Zn/Cd- and the Cu-thioneins. Ciliates harbor the largest MT gene/protein family reported so far, in-cluding 5 paralogs that exhibit relatively low seq[...]texto impreso
We report a summary of the symposium “Stress and Protists: No life without stress”, which was held in September 2015 on the VII European Congress of Protistology in partnership with the International Society of Protistologists (Seville, Spain). [...]texto impreso
Gutiérrez Fernández, Juan Carlos ; Francisco Martínez, Patricia de ; Amaro Torres, Francisco ; Díaz, Silvia ; Martín González, Ana María | Elsevier | 2018-10-16In the present review, we discussed the concept of metallothionein (MT) and analyzed the structural and functional diversity of microbial MTs, grouping them into three main groups; bacteria, fungi, and protists. Structural diversity is analyzed [...]texto impreso
Cubas-Gaona, Liliana L. ; Francisco Martínez, Patricia de ; Martín-González, Ana María ; Gutiérrez Fernández, Juan Carlos | MDPI | 2020-07-05In the present work, an extensive analysis of the putative glutathione peroxidases (GPx) of the eukaryotic microorganism model Tetrahymena thermophila is carried out. A comparative analysis with GPx present in other Tetrahymena species and other[...]texto impreso
Francisco Martínez, Patricia de ; Melgar, Laura María ; Díaz del Toro, Silvia ; Martín González, Ana María ; Gutiérrez Fernández, Juan Carlos | BioMed Central | 2016-05-16Background: Ciliate metallothioneins (MTs) are included in family 7 of the MT superfamily. This family has been divided into two main subfamilies: 7a or CdMTs and 7b or CuMTs. All ciliate MTs reported have been isolated from different Tetrahymen[...]
