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Ivorra, Benjamin ; Mohammadi, Bijan ; Santiago, Juan G. ; Hertzog, David E. | Université de technologie de Troyes | 2005A new semi-deterministic global optimization algorithm is used for the design of a fast-micro-mixer. Our aim is to reduce the mixing time for protein folding by modifying the device shape.texto impreso
Ivorra, Benjamin ; López Redondo, Juana ; Ramos del Olmo, Ángel Manuel ; Santiago, Juan G. | AIP Publishing | 2016We consider a particular hydrodynamic focusing microfluidic mixer used to initiate the folding process of individual proteins, which has been designed in a previous work and exhibited a mixing time of 0.1 ?s. The aim of the current paper is twof[...]texto impreso
Hertzog, David E. ; Ivorra, Benjamin ; Mohammadi, Bijan ; Bakajin, Olgica ; Santiago, Juan G. | American Chemical Society | 2006-07-01We have applied an optimization method in conjunction with numerical simulations to minimize the mixing time of a microfluidic mixer developed for protein folding studies. The optimization method uses a semideterministic algorithm to find the gl[...]texto impreso
In this paper we reformulate global optimization problems in terms of boundary value problems (BVP). This allows us to introduce a new class of optimization algorithms. Indeed, current optimization methods, including non-deterministic ones, can [...]texto impreso
Ivorra, Benjamin ; Ramos, Angel M ; López Redondo, Juana ; Santiago, Juan G. | Cornell University Library | 2015-01We consider a microfluidic mixer based on hydrodynamic focusing, which is used to initiate the folding process of individual proteins. The folding process is initiated by quickly diluting a local denaturant concentration, and we define mixing ti[...]
