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Manterola, Andrea ; Bernal Chico, Ana ; Cipriani, Raffaela ; Canedo Antelo, Manuel ; Moreno García, Álvaro ; Martín Fontecha, Mar ; Pérez Cerdá, Fernando ; Sánchez Gómez, María Victoria ; Ortega Gutiérrez, Silvia ; Brown, J. Mark ; Hsu, Ku-Lung ; Cravatt, Benjamin ; Matute, Carlos ; Mato, Susana | Elsevier | 2018-08Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which tissue pathology suggests both immune-dependent attacks to oligodendroglia and primary oligodendrocyte demise. The endocannabinoid system has been crucially [...]texto impreso
Hernández Torres, Gloria ; Enríquez Palacios, Ernesto ; Mecha Rodríguez, Miriam ; Feliú Martínez, Ana ; Rueda Zubiaurre, Ainoa ; Angelina Querencias, Alba ; Martín Cruz, Leticia ; Martín Fontecha, María del Mar ; Palomares, Oscar ; Guaza Rodríguez, Carmen ; Peña Cabrera, Eduardo ; López Rodríguez, María L. ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2018-05-07Serotonin (5-HT) modulates key aspects of the immune system. However, its precise function and the receptors involved in the observed effects have remained elusive. Among the different serotonin receptors, 5-HT1A plays an important role in the i[...]texto impreso
Marín Ramos, Nagore Isasbel ; Piñar Pinedo, María del Carmen ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Canales Mayordomo, Ángeles ; Algar Lizana, Sergio ; Mayo Mariscal de Gante, Paloma P. ; Jiménez-Barbero, Jesús ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Pardo Carrasco, Leonardo ; Ortega Gutiérrez, Silvia ; Viso Beronda, Alma ; López Rodríguez, María Luz | Wiley | 2017-01-31Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent[...]texto impreso
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y desarrollo de nuevos inhibidores del proceso de recaptación de anandamida potentes y selectivos que han permitido estudiar este fenómeno así como evaluar su potencial aplicabilidad[...]texto impreso
Martín Fontecha, María del Mar ; Angelina Querencias, Alba ; Rückert, Beate ; Rueda Zubiaurre, Ainoa ; Martín Cruz, Leticia ; Veen, Willem van de ; Akdis, Mübeccel ; Ortega Gutiérrez, Silvia ; López Rodríguez, María Luz ; Akdis, Cezmi A. ; Palomares, Oscar | American Chemical Society (ACS) | 2018-02-21The human endogenous cannabinoid system (ECS) regulates key physiological processes and alterations in its signaling pathways, and endocannabinoid levels are associated with diseases such as neurological and neuropsychiatric conditions, cancer, [...]texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]texto impreso
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González Gil, Inés ; Zian, Debora ; Vázquez Villa, Henar ; Ortega Gutiérrez, Silvia ; López Rodríguez, María L. | Royal Society of Chemistry (UK) | 2015Lysophospholipids are lipid molecules that are receiving growing attention because, in addition to their structural function in the cell membrane, they are now regarded as important regulators for diverse biological functions through activation [...]texto impreso
Camicia, Federico ; Celentano, Ana M. ; Johns, Malcolm E. ; Chan, John D. ; Maldonado, Lucas ; Vaca, Hugo ; Siervi, Nicolás Di ; Kamenetzky, Laura ; Gamo Albero, Ana María ; Ortega Gutiérrez, Silvia ; Martín Fontecha, María del Mar ; Davio, Carlos ; Marchant, Jonathan S. ; Rosenzvit, Mara C. | Public Library Science | 2018-02-09Background: Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable [...]
