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Marín Ramos, Nagore Isasbel ; Piñar Pinedo, María del Carmen ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Canales Mayordomo, Ángeles ; Algar Lizana, Sergio ; Mayo Mariscal de Gante, Paloma P. ; Jiménez-Barbero, Jesús ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Pardo Carrasco, Leonardo ; Ortega Gutiérrez, Silvia ; Viso Beronda, Alma ; López Rodríguez, María Luz | Wiley | 2017-01-31Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent[...]texto impreso
texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]
