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Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology

Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Villa, Pedro, de la ; Díaz Hernández, Juan Ignacio ; Miras Portugal, María Teresa ; Pintor, Jesús | 2015-09-06

Purpose: To study retinal extracellular ATP levels and to assess the changes in the vesicular nucleotide transporter (VNUT) expression in a murine model of glaucoma during the development of the disease. Methods: Retinas were obtained from glauc[...]

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Regulation of proteasome activity by P2Y2 receptor underlies the neuroprotective effects of extracellular nucleotides

Diego García, Laura de ; Ramírez Escudero, Mercedes ; Sebastián Serrano, Álvaro ; Díaz Hernández, Juan Ignacio ; Pintor, Jesús ; Lucas Lozano, José J. ; Díaz Hernández, Miguel | Elsevier | 2017-01

The Ubiquitin-Proteasome System (UPS) is essential for the regulation of the cellular proteostasis. Indeed, it has been postulated that an UPS dysregulation is the common mechanism that underlies several neurological disorders. Considering that [...]

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