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Ruwisch, Jannik ; Sehlmeyer, Kirsten ; Roldán López, Nuria ; García Álvarez, Begoña ; Pérez-Gil, Jesús ; Weaver, Timothy E. ; Ochs, Matthias ; Knudsen, Lars ; López-Rodríguez, Elena | American Thoracic Society | 2020-01-10Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice and alveolar l[...]texto impreso
Roldán López, Nuria ; Pérez Gil, Jesús ; Morrow, Michael R. ; García Álvarez, Begoña | Elsevier | 2017-08-22Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol can be deleterious for LS function, a condition that is reversed by the presence of the lipopeptide SP-C. In this work, the structure of LS-mimicking me[...]texto impreso
Roldán López, Nuria ; Nyholm, Thomas K. M. ; Slotte, J. Peter ; Pérez Gil, Jesús ; García Álvarez, Begoña | BIOPHYSICAL SOCIETY | 2016-10-18To allow breathing and prevent alveolar collapse, lung surfactant (LS) develops a complex membranous system at the respiratory surface. LS is defined by a specific protein and lipid composition, including saturated and unsaturated phospholipid s[...]texto impreso
Olmeda Lozano, Bárbara ; García Álvarez, Begoña ; Gómez, Manuel J. ; Martínez Calle, Marta ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Federation of American Societies for Experimental Biology | 2017Surfactant protein B (SP-B), from the saposin-like family of proteins, is essential to facilitate the formation and proper performance of surface active films at the air-liquid interface of mammalian lungs, and lack of or deficiency in this prot[...]texto impreso
Olmeda Lozano, Bárbara ; García Álvarez, Begoña ; Gómez, M. J. ; Martínez Calle, Marta | Federation of American Societies for Experimental Biology (FASEB) | 2015Surfactant protein B (SP-B), from the saposin-like family of proteins, is essential to facilitate the formation and proper performance of surface active films at the air-liquid interface of mammalian lungs, and lack of or deficiency in this prot[...]texto impreso
Roldán López, Nuria ; Goormaghtigh, Erik ; Pérez Gil, Jesús ; García Álvarez, Begoña | Elsevier | 2015-01Surfactant protein C (SP-C) has been regarded as the most specific protein linked to development of mammalian lungs, and great efforts have been done to understand its structure–function relationships. Previous evidence has outlined the importan[...]
