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García-Segura, Luis Miguel ; Veiga, Sergio ; Sierra, Amanda ; Melcangi, Roberto C. ; Azcoitia Elías, Iñigo | Elsevier | 2003-09Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme cataly[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Elsevier | 2015-06Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective str[...]texto impreso
Cermenati, Gaia ; Audano, Matteo ; Giatti, Silvia ; Carozzi, Valentina ; Porretta Serapiglia, Carla ; Pettinato, Emanuela ; Ferri, Cinzia ; D'Antonio, Maurizio ; De Fabiani, Emma ; Crestani, Maurizio ; Scuranti, Samuele ; Sáez, Enrique ; Azcoitia Elías, Iñigo ; Calavetti, Guido ; García Segura, Luis Miguel ; Melcangi, Roberto C. ; Caruso, Donatella ; Mitro, Nico | Science Direct | 2015-04-07Myelin is a membrane characterized by high lipid content to facilitate impulse propagation. Changes in myelin fatty acid (FA) composition have been associated with peripheral neuropathy, but the specific role of peripheral nerve FA synthesis in [...]texto impreso
Mitro, Nico ; Cermenati, Gaia ; Brioschi, Elizabetta ; Abbiati, Federico ; Audano, Matteo ; Giatti, Silvia ; Crestani, Maurizio ; De Fabiani, Emma ; Azcoitia Elías, Iñigo ; García-Segura, Luis Miguel ; Caruso, Donatella ; Melcangi, Roberto C. | Elsevier | 2014-09Diabetic peripheral neuropathy causes a decrease in the levels of dihydroprogesterone and 5- androstane-3,17-diol (3-diol) in the peripheral nerves. These two neuroactive steroids exert protective effects, by mechanisms that still remain elusive[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Spezzano, Roberto ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Endocrine Society | 2016The incidence of traumatic brain injuries (TBIs) in humans has rapidly increased in the last ten years. The most common causes are falls and car accidents. Approximately 80 000-90 000 persons per year will suffer some permanent disability as a r[...]
