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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto | BioMed Central Ltd. | 2014-07-26Background: Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanisms with neurodegenerativ[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
Hoz Montañana, María Rosa de ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Rojas López, María Blanca ; Salazar Corral, Juan José ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-12-18In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in both the treated and the normotensive untreated contralateral eye have morphological signs of activation and up-regulation of MHC-II expression in comparis[...]
