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Devereaux, P.J. ; Mrkobrada, M. ; Sessler, D.I. ; Leslie, K. ; Alonso-Coello, P. ; Kurz, A. ; Villar, J.C. ; Sigamani, A. ; Biccard, B.M. ; Meyhoff, C.S. ; Parlow, J.L. ; Guyatt, G. ; Robinson, A. ; Garg, A.X. ; Rodseth, R.N. ; Botto, F. ; Lurati Buse, G. ; Xavier, D. ; Chan, M.T.V. ; Tiboni, M. ; Cook, D. ; Kumar, P.A. ; Forget, P. ; Malaga, G. ; Fleischmann, E. ; Amir, M. ; Eikelboom, J. ; Mizera, R. ; Torres, D. ; Wang, C.Y. ; VanHelder, T. ; Paniagua, P. ; Berwanger, O. ; Srinathan, S. ; Graham, M. ; Pasin, L. ; Le Manach, Y. ; Gao, P. ; Pogue, J. ; Whitlock, R. ; Lamy, A. ; Kearon, C. ; Baigent, C. ; Chow, C. ; Pettit, S. ; Chrolavicius, S. ; Yusuf, S. | Massachusetts Medical Society | 2020-06-10T18:12:14ZBACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a 2-by-2[...]texto impreso
Devereaux, P.J. ; Sessler, D.I. ; Leslie, K. ; Kurz, A. ; Mrkobrada, M. ; Alonso-Coello, P. ; Villar, J.C. ; Sigamani, A. ; Biccard, B.M. ; Meyhoff, C.S. ; Parlow, J.L. ; Guyatt, G. ; Robinson, A. ; Garg, A.X. ; Rodseth, R.N. ; Botto, F. ; Lurati Buse, G. ; Xavier, D. ; Chan, M.T.V. ; Tiboni, M. ; Cook, D. ; Kumar, P.A. ; Forget, P. ; Malaga, G. ; Fleischmann, E. ; Amir, M. ; Eikelboom, J. ; Mizera, R. ; Torres, D. ; Wang, C.Y. ; VanHelder, T. ; Paniagua, P. ; Berwanger, O. ; Srinathan, S. ; Graham, M. ; Pasin, L. ; Le Manach, Y. ; Gao, P. ; Pogue, J. ; Whitlock, R. ; Lamy, A. ; Kearon, C. ; Chow, C. ; Pettit, S. ; Chrolavicius, S. ; Yusuf, S. | Massachusetts Medical Society | 2020-06-10T18:12:14ZBACKGROUND: Marked activation of the sympathetic nervous system occurs during and after non-cardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; Tsang, Victor C. W. ; O'Neal, Seth E. ; Llanos-Zavalaga, Fernando ; Gonzalvez, Guillermo ; Romero, Jaime ; Rodriguez, Silvia ; Moyano, Luz M. ; Ayvar, Viterbo ; Diaz, Andre ; Hightower, Allen ; Craig, Philip S. ; Lightowlers, Marshall W. ; Gauci, Charles G. ; Leontsini, Elli ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-06T14:45:33ZBACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts[...]texto impreso
Garcia, Hector H. ; O'Neal, Seth E. ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-22T14:55:49Ztexto impreso
Diacon, A.H. ; Pym, A. ; Grobusch, M.P. ; De Los Rios, J.M. ; Gotuzzo, E. ; Vasilyeva, I. ; Leimane, V. ; Andries, K. ; Bakare, N. ; De Marez, T. ; Haxaire-Theeuwes, M. ; Lounis, N. ; Meyvisch, P. ; De Paepe, E. ; Van Heeswijk, R.P.G. ; Dannemann, B. | Massachusetts Medical Society | 2020-06-10T18:12:14ZBACKGROUND: Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred ba[...]texto impreso
Lacerda, M.V.G. ; Llanos-Cuentas, A. ; Krudsood, S. ; Lon, C. ; Saunders, D.L. ; Mohammed, R. ; Yilma, D. ; Pereira, D.B. ; Espino, F.E.J. ; Mia, R.Z. ; Chuquiyauri, R. ; Val, F. ; Casapía, M. ; Monteiro, W.M. ; Brito, M.A.M. ; Costa, M.R.F. ; Buathong, N. ; Noedl, H. ; Diro, E. ; Getie, S. ; Wubie, K.M. ; Abdissa, A. ; Zeynudin, A. ; Abebe, C. ; Tada, M.S. ; Brand, F. ; Beck, H.-P. ; Angus, B. ; Duparc, S. ; Kleim, J.-P. ; Kellam, L.M. ; Rousell, V.M. ; Jones, S.W. ; Hardaker, E. ; Mohamed, K. ; Clover, D.D. ; Fletcher, K. ; Breton, J.J. ; Ugwuegbulam, C.O. ; Green, J.A. ; Koh, G.C.K.W. | Massachusetts Medical Society | 2019-12-06T20:57:48ZBACKGROUND Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed “radical cure”). Tafenoquine is a single-dose 8-[...]texto impreso
Lacerda, Marcus V. G. ; Llanos-Cuentas, Alejandro ; Krudsood, Srivicha ; Lon, Chanthap ; Saunders, David L. ; Mohammed, Rezika ; Yilma, Daniel ; Batista Pereira, Dhelio ; Espino, Fe E. J. ; Mia, Reginaldo Z. ; Chuquiyauri, Raúl ; Val, Fernando ; Casapía, Martin ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Buathong, Nillawan ; Noedl, Harald ; Diro, Ermias ; Getie, Sisay ; Wubie, Kalehiwot M. ; Abdissa, Alemseged ; Zeynudin, Ahmed ; Abebe, Cherinet ; Tada, Mauro S. ; Brand, Francoise ; Beck, Hans-Peter ; Angus, Brian ; Duparc, Stephan ; Kleim, Jorg-Peter ; Kellam, Lynda M. ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Mohamed, Khadeeja ; Clover, Donna D. ; Fletcher, Kim ; Breton, John J. ; Ugwuegbulam, Cletus O. ; Green, Justin A. ; Koh, Gavin C. K. W. | Massachusetts Medical Society | 2019-07-04T17:00:24ZBACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8[...]texto impreso
Llanos-Cuentas, Alejandro ; Lacerda, Marcus V. G. ; Hien, Tran T. ; Velez, Ivan D. ; Namaik-Larp, Chayadol ; Chu, Cindy S. ; Villegas, Maria F. ; Val, Fernando ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Chuquiyauri, Raúl ; Casapía, Martin ; Nguyen, Chau H. ; Aruachan, Sandra ; Papwijitsil, Ratchadaporn ; Nosten, Francois H. ; Bancone, Germana ; Angus, Brian ; Duparc, Stephan ; Craig, Graham ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Clover, Donna D. ; Kendall, Lindsay ; Mohamed, Khadeeja ; Koh, Gavin C. K. W. ; Wilches, Viviana M. ; Breton, John J. ; Green, Justin A. | Massachusetts Medical Society | 2019-07-04T17:01:20ZBACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure." METHODS: We performed a phase 3, pros[...]texto impreso
Llanos-Cuentas, A. ; Lacerda, M.V.G. ; Hien, T.T. ; Velez, I.D. ; Namaik-Larp, C. ; Chu, C.S. ; Villegas, M.F. ; Val, F. ; Monteiro, W.M. ; Brito, M.A.M. ; Costa, M.R.F. ; Chuquiyauri, R. ; Casapía, M. ; Nguyen, C.H. ; Aruachan, S. ; Papwijitsil, R. ; Nosten, F.H. ; Bancone, G. ; Angus, B. ; Duparc, S. ; Craig, G. ; Rousell, V.M. ; Jones, S.W. ; Hardaker, E. ; Clover, D.D. ; Kendall, L. ; Mohamed, K. ; Koh, G.C.K.W. ; Wilches, V.M. ; Breton, J.J. ; Green, J.A. | Massachusetts Medical Society | 2019-12-06T20:57:47ZBACKGROUND Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed “radical cure.” METHODS We performed a phase 3, prospec[...]
