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Blanco Imperiali, Ayelén M. ; Sánchez Bretaño, Aída ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel | Wiley Periodicals | 2016Ghrelin O-acyltransferase (GOAT) is the enzyme responsible for acylation of ghrelin, a gut-brain hormone with important roles in many physiological functions in vertebrates. Many aspects of GOAT remain to be elucidated, especially in fish, and p[...]texto impreso
Blanco Imperiali, Ayelén M. ; Cortés, Raul ; Bertucci, Juan Ignacio ; Sánchez, Elisa ; Valenciano González, Ana Isabel ; Cerdá-Reverter, José Miguel ; Delgado Saavedra, María Jesús | Springer | 2020-02Ghrelin (GRL) is a gut-brain hormone with a role in a wide variety of physiological functions in mammals and fish, which points out the ghrelinergic system as a key element for the appropriate biological functioning of the organism. However, man[...]texto impreso
La ingesta está sometida a un control complejo en el que intervienen numerososreguladores neurales, endocrinos y neuroendocrinos. Entre ellos, la ghrelina, sintetizadaprincipalmente por el estómago, o su equivalente en especies que carecen de él[...]texto impreso
Blanco Imperiali, Ayelén M. ; Gómez Boronat, Miguel ; Alonso Gómez, Ángel Luis ; Yufa, Roman ; Unniappan, Suraj ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel | Public Library of Science | 2017-02-08Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin’s physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this[...]texto impreso
Blanco Imperiali, Ayelén M. ; Gómez-Boronat, Miguel ; Madera, Diego ; Valenciano González, Ana Isabel ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús | American Physiological Society | 2018-02Nocturnin (NOC) is a unique deadenylase with robust rhythmic expression involved in the regulation of metabolic processes in mammals. Currently, the possible presence of NOC in fish is unknown. This report aimed to identify NOC in a fish model, [...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Ramesh, Naresh ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel ; Unniappan, Suraj | Springer Nature | 2017-03-24Glucose homeostasis is an important biological process that involves a variety of regulatory mechanisms. This study aimed to determine whether ghrelin, a multifunctional gut-brain hormone, modulates intestinal glucose transport in goldfish (Cara[...]texto impreso
Sánchez Bretaño, Aída ; Blanco Imperiali, Ayelén M. ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús ; Kah, Olivier ; Isorna Alonso, Esther | The Company of Biologists | 2017The liver is the most important link between the circadian system and metabolism. As a food-entrainable oscillator, the hepatic clock needs to be entrained by food-related signals. The objective of the present study was to investigate the possib[...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Sánchez Bretaño, Aída ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel ; Unniappan, Suraj | Elsevier | 2017-02-15Ghrelin, a multifunctional gut-brain hormone, is involved in the regulation of gastric functions in mammals. This study aimed to determine whether ghrelin modulates digestive enzymes in goldfish (Carassius auratus). Immunofluorescence microscopy[...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Valenciano González, Ana Isabel ; Delgado, María Jesús ; Unniappan, Suraj | Elsevier | 2017-07Ghrelin is an important gut-derived hormone with an appetite stimulatory role, while most of the intestinal hormones, including cholecystokinin (CCK), peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), are appetite-inhibitors. Whether these i[...]texto impreso
Sánchez Bretaño, Aída ; Blanco Imperiali, Ayelén M. ; Unniappan, Suraj ; Kah, Olivier ; Gueguen, Marie-M. ; Bertucci, Juan I. ; Alonso Gómez, Ángel Luis ; Valenciano González, Ana Isabel ; Isorna Alonso, Esther ; Delgado, María J. | Public Library of Sciences (PLOS) | 2015-10-27Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) to regulate a wide variety of biological processes in fish. Despite these prominent physiological roles, no studies have reported the anatomi[...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel ; Unniappan, Suraj | Elsevier | 2016-05The macronutrient composition of diets is a very important factor in the regulation of body weight and metabolism. Several lines of research in mammals have shown that macronutrients differentially regulate metabolic hormones, including ghrelin [...]
