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Merino, José Joaquín ; Roncero Romero, César ; Oset Gasque, María Jesús ; Naddaf, Ahmad ; González Prieto, María Pilar | MDPI | 2014-02-12In the present work, we have studied whether cell death could be induced in cortical neurons from rats subjected to different period of O2 deprivation and low glucose (ODLG). This “in vitro” model is designed to emulate the penumbra area under i[...]texto impreso
Merino, José Joaquín ; Bellver Landete, Víctor ; Oset Gasque, María Jesús ; Cubelos, Beatriz | Wiley | 2015In the adult brain, neural progenitor cells (NPCs) reside in the subventricular zone (SVZ) of the lateral ventricles, the dentate gyrus and the olfactory bulb. Following CNS insult, NPCs from the SVZ can migrate along the rostral migratory strea[...]texto impreso
Pérez Rodríguez, Rocío ; Oliván, A. M. ; Roncero Romero, César ; Morón Oset, J. ; González Prieto, María Pilar ; Oset Gasque, María Jesús | Elsevier | 2014-01-28Previous work from our group stated that nitric oxide (NO), via cytokines, induces apoptosis in chromaffin cells by a mechanism involving iNOS, nNOS, and NF-?B. In this paper the involvement of glutamate as a possible intracellular trigger of ne[...]texto impreso
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Chioua, Mourad ; Pérez Peña, Javier ; García Font, Nuria ; Moraleda, Ignacio ; Iriepa, Isabel ; Soriano, Elena ; Marco Contelles, José ; Oset Gasque, María Jesús | Future Science | 2015Aim: Due to the complex nature of Alzheimer’s disease, there is a renewed search for multipotent, nonhepatotoxic tacrines. Results: This paper describes the synthesis and in vitro biological evaluation of eight new racemic 3-methyl-4-aryl-2,4,6,[...]texto impreso
Merino, José Joaquín ; Arce, Carmen ; Naddaf, Ahmad ; Bellver Landete, Víctor ; González, María Pilar ; Oset Gasque, María Jesús | Public Library of Science | 2014Background: The discovery that nitric oxide (NO)functions as a signalling molecule in the nervous system has radically changed the concept of neuronal communication. NO induces the release of amino acid neurotransmitters but the underlying mecha[...]texto impreso
Oset Gasque, María Jesús ; González Prieto, María Pilar ; Pérez Peña, Javier ; García Font, Nuria ; Romero Martínez, Alejandro ; Pino Sans, Javier del ; Ramos, Eva ; Hadjipavlou-Litina, Dimitra ; Soriano, Elena ; Chioua, Mourad ; Samadi, Abdelouahid ; Raghuvanshi, Dushyant S. ; Singh, Krishna N. ; Marco Contelles, José | Elsevier | 2014-01-08The pharmacological analysis of racemic chromenotacrines (CT) 1e7, bearing the 11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ol ring skeleton, in a series of experiments targeted to explore their potential use for the treatm[...]
