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Gil Ordóñez, Ana ; Martín Fontecha, Mar ; Ortega Guitérrez, Silvia ; López Rodríguez, María Luz | Elsevier | 2018-11Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG). Besides this role, MAGL has progressively acquired a growing imp[...]texto impreso
Cellular senescence is a biological irreversible process that appears after cellular stress and stops the proliferation of dysfunctional or damaged cells. Senescent cells are accumulated in our body with aging, so the regulation of this process [...]texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]
