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Moreno-Delgado, David ; Puigdellívol, Mar ; Moreno, Moreno ; Rodríguez-Ruiz, Mar ; Botta, Joaquín ; Gasperini, Paola ; Chiarlone, Anna ; Howell, Lesley A. ; Scarselli, Marco ; Casadó, Vicent ; Cortés, Antoni ; Ferré, Sergi ; Guzmán, Manuel ; Lluís, Carmen ; Alberch, Jordi ; Canela, Enric I. ; Ginés, Silvia ; McCormick, Peter J. | eLife Sciences Publications | 2020-06-09Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of[...]texto impreso
González Vera, Juan Antonio ; Medina Muñoz, Rocío Almudena ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Fuente Mendizábal, Tania de la ; Vázquez Villa, Henar ; García Cárceles, Javier ; Botta, Joaquín ; McCormick, Peter J. ; Benhamú Salama, Bellinda ; Pardo Carrasco, Leonardo ; López Rodríguez, María Luz | Nature Publishing Group | 2017Serotonin 5-HT 6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's diseas[...]
