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A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors.

Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Vicente, Francisca ; Monteiro, Maria Cândida ; Tormo, José R. ; Cantizani, Juan ; Molina, María ; Cid, Víctor J. | 2012-06-15

The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by generating the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate. This pathway is implicated in multiple aspect[...]

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