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Villegas Díaz, María Rocío ; Baeza, Alejandro ; Usategui Corral, Alicia ; Ortiz-Romero, Pablo L. ; Pablos, José L. ; Vallet Regí, María | Elsevier | 2018-05-04Fibrosis is a common lesion in different pathologic diseases and defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. The FDA and EMA approved the use of [...]texto impreso
Villegas Díaz, María Rocío ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2015-11-04Poor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alt[...]texto impreso
Esta tesis doctoral se centra en el diseño, síntesis y evaluación de nanosistemas inteligentes para el tratamiento de enfermedades complejas como el cáncer y la fibrosis. El cáncer es una enfermedad maligna y multifacética con una incidencia sig[...]texto impreso
Villegas Díaz, María Rocío ; Baeza García, Alejandro ; Nouredinne, Achraf ; Durfee, Paul N ; Butler, Kimberly S ; Agola, Jacob Ongudi ; Brinker, C.Jeffrey ; Vallet Regí, María | American Chemical Society | 2018-01-09The high density of the extracellular matrix in solid tumors is an important obstacle to nanocarriers for reaching deep tumor regions and has severely limited the efficacy of administrated nanotherapeutics. The use of proteolytic enzymes prior t[...]texto impreso
The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target[...]
