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Backer, Lynn de ; Cerrada, Alejandro ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | Elsevier | 2015Many pathologies of the respiratory tract are inadequately treated with existing small molecule-based therapies. The emergence of RNA interference (RNAi) enables the post-transcriptional silencing of key molecular disease factors that cannot rea[...]texto impreso
Guagliardo, Roberta ; Merckx, Pieterjan ; Zamborlin, Agata ; Backer, Lynn de ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | MDPI | 2019-08-23Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by vario[...]
