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Ruiz-de-la-Herrán, Javier ; Tomé-Amat, Jaime ; Lázaro Gorines, Rodrigo ; Gavilanes, José G. ; Lacadena, Javier | MDPI | 2019-10-12Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immun[...]texto impreso
Tomé-Amat, Jaime ; Herrero-Galán, Elías ; Oñaderra, Mercedes ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-06Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of [...]texto impreso
Tomé-Amat, Jaime ; Ruiz de la Herrán, Javier ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-04Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects. Different studies have shown how toxins can follow different in[...]
