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Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins

Ruiz-de-la-Herrán, Javier ; Tomé-Amat, Jaime ; Lázaro Gorines, Rodrigo ; Gavilanes, José G. ; Lacadena, Javier | MDPI | 2019-10-12

Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immun[...]

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